I do not know I this is possible or not.

I am using version 1.3 alpha on Windows 10 OS.

my goal is to easily move a path's center of to a specific node that is on the same path. Not to the start nor end nodes of the Path. Not to the edges nor corners of the bounding box of the path. Is this do-able ... easily? Is there some trick or steps to accomplish this?

Maybe even a means to set guide lines to a specific node on a Path. And then use that intersection of the guides as a step towards positioning the center of rotation   for it that way.

The path may be an open path with several number of nodes . Or it may be a closed shape which has several nodes.

Thank you for your ideas and your help.

I'd activate snapping for rotation centers and snapping for nodes (smooth and/or cusp), then drag the rotation center to any node to snap.

To restore the rotation center to the object center, Shift-Click on the rotation crosshairs.

Thank you very much for your super and quick answer, Tyler.