I have the same error all the time:

C:\Program Files\Inkscape\bin\pythonw.exe: can't find '__main__' module in 'C:\\Program Files\\Inkscape'

I have installed and reinstalled Inkscape multiple times checking the Python option and it still doesn't work.

1. Describe your OS (your computer's Operating System: Mac/Windows/Linux/etc. & version).
2. Describe the version of Inkscape and the installer you used (the file you downloaded from the website: .msi/.exe/.zip/other ). 
3. Describe any special hardware being used, like tablet/stylus or multiple monitors.

Bonus points, if you:

• Attach* a screenshot of the issue.
• Attach* an example SVG file that has the issue.

1. Windows
2. Inkscape 1.2 (dc2aedaf03, 2022-05-15). .exe installer.

This issue has been fixed

It was a problem with the file that I downloaded. 

I had the same problem and re-downloading Inkscape .msi again fixed the problem.

I am having this same problem. I am using windows 10 and I have tried both the MSI and EXE copies of both 1.2.2 AND 1.2.1. Any suggestions?

check if the id from inx file is unique , this fix the error on my source code.

I'm sorry, I am not sure I follow, can you clarify for a noob?